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| Tretinoin |
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| all-trans-Retinoic acid |
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| 302-79-4 |
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USE
1. Dermatology
Tretinoin is most commonly used as a form of acne treatment.[citation needed] It was the first retinoid developed for this type of topical use. It is used by some as a hair loss treatment and also a component of many commercial products that are advertised as being able to slow skin aging or remove wrinkles.[citation needed]Topical tretinoin is also used to treat and reduce the appearance of stretch marks by increasing collagen production in the dermis.
2. Leukemia
In addition, tretinoin (marketed as Vesanoid) is also used to treat at least one form of cancer (acute promyelocytic leukemia (APML), also called acute myeloid leukemia subtype M3), usually together with other drugs, by causing the immature blood cells to differentiate (i.e. mature) and die. The pathology of the leukemia is due to the highly proliferative immature cells
retinoic acid drives these cells to develop into functional cells, which helps to alleviate the disease. It is usually prescribed over 3 months at about 8 capsules per day.
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FORMULA: C20H28O2
SYNONYMS
Retinoic acid,
Vitamin A acid
all-trans-Retinoic acid
INTRODUCTION
Tretinoin is the acid form of vitamin A and so also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel (brand name Retin-A). It is also used to treat acute promyelocytic leukemia (APML).
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