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Azelaic Acid
Anchoic Acid
123-99-9
Acne Treatment
Azelaic acid is used to treat mild to moderate acne, i.e. both comedonal acne and inflammatory acne. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.

Hair Loss
Azelaic acid may be useful as a hair growth stimulant. A research report by Stamatiadis in 1988 suggested that azelaic acid (and combinations of it, with zinc ion and vitamin B6) was a strong type I 5-alpha reductase (5-AR) inhibitor. The enzyme, 5-AR (both Types I and II) convert testosterone to dihydrotestosterone (DHT). DHT has been shown to contribute to prostate enlargement (benign prostatic hyperplasia, BPH) and to damage hair follicles.
Empirical Formula: C9H16O4

SYNONYMS: Anchoic Acid
Nonanedioic Acid.

Azelaic acid is:

* Antibacterial: it reduces the growth of bacteria in the follicle (Propionibacterium acnes and Staphylococcus epidermidis).

* Keratolytic & comedolytic: it returns to normal, the disordered growth of the skin cells, lining the follicle.

*Scavenger of free radicals and reduces inflammation.

* Reduces pigmentation: it is particularly useful for darker-skinned patients, who have melasma, or whose acne spots leave persistent brown marks known as actinic lentigenes.

* Non-toxic, and is well tolerated by most patients.

Azelaic acid does not result in:

* Bacterial resistance to antibiotics.
* Reduction in sebum production.
* Photosensitivity (easy sunburn).
* Staining of skin or clothing.
* Bleaching of normal skin or clothing.

Because 20% azelaic acid can be a skin irritant, it should be used only when prescribed by a physician.



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