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Tiamulin fumarate
C32H51NO8S
55297-96-6
Tiamulin is a prokaryotic ribosome inhibitor that acts by blocking the initiation of polypeptide chain formation, thus preventing the synthesis of key enzymes and other proteins. Tiamulin is rapidly distributed in the body. The half-life in serum is several hours and virtually disappears within 24 hours. High concentrations of tiamulin are found in lung (target organ), liver and kidney (detoxifying organ)
much lower concentrations are found in muscle and some other tissues. With ad libitum feeding tiamulin concentrations are maintained at a relatively steady-state. Following withdrawal of the medicine, tiamulin rapidly depletes from all organs and tissues. There is no accumulation of tiamulin in the blood or any organs or tissues following repeated or long-term administration of tiamulin-medicated feed.

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