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| J 147 powder |
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| C18H17F3N2O2 |
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| 1146963-51-0 |
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J147 Powder is a synthetic derivative of curcumin, which is a component of the curry spice turmeric. J147 Powder is essentially a Curcumin and Cyclohexyl-Bisphenol A (CBA) derivative that is both neurogenic and neuroprotective.
J147 Powder has been shown to significantly improve cognitive impairment in elderly Alzheimer¡¯s patients. These findings are based on accelerated aging animal models. J147 Powder is an orally active neurotrophic medication that reverses cognitive impairment.
Curcumin is a polyphenol that is found in turmeric and ginger.
Curcumin has several demonstrated benefits in the treatment of different diseases, however there are evident limitations due to its weak capacity to pass the Blood-Brain Barrier (BB).
J147 Powder can cross the BBB into the brain (strong) and induce neuronal stem cell production.
J147 Powder, unlike the current Alzheimer¡¯s Disease medications, is neither an acetylcholinesterase inhibitor nor a phosphodiesterase inhibitor, but it improves cognition with a short-term treatment.
Benefits:
¨çEnhances Mitochondrial Function And Life span
J147 Powder is highly efficient at reducing oxidative stress and enhancing mitochondrial performance.
¨è Prevents Alzheimer¡¯s Disease
J147 Powder cures cognitive impairment in an Alzheimer¡¯s disease mice model (AD).
J147 Powder can promote Amyloid-Beta (A) metabolism and reduce levels in the brain by lowering -Secretase protein levels (BACE).
J147 Powder can protect BBB permeability homeostasis and improve vascular function in animal models of Alzheimer¡¯s disease.
J147 Powder can also considerably raise Docosahexaenoic Acid (DHA) levels in the brain.
It can help restore Glutamate levels in the brain (which are produced from the TCA intermediate -ketoglutarate).
¨éImproves Memory
It improves cognition in both Alzheimer¡¯s disease mice and normal-aged animal models.
J147 Powder can restore significant cognitive impairments in even the most elderly animal models.
J-147 can also help with spatial memory and Long-Term Potentiation (LTP).
¨êBrain Growth
J 147 Powder has the ability to enhance and stimulate synaptic plasticity in the brain.
J 147 Powder promotes synaptic plasticity by maintaining Synaptophysin expression (a synaptic vesicle protein that is reduced in both aging and AD and is considered a biomarker for synapse loss).
J-147 Powder promotes brain growth by boosting levels of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) (BDNF).
¨ëProtects Neurons
J 147 Powder does not require BDNF to be neuroprotective.
J 147 Powder also protects neurons from glutathione (GSH) deficiency.
J-147 Powder protects the brain against glucose deprivation.
In AD brains, 5-Lipoxygenase (5-LOX) recruits more immune cells to cause an inflammatory response, and Heme Oxygenase 1 (HO-1) acts as a pro-oxidant rather than an antioxidant.
Curcumin derivative J147 Powder has the ability to lower HO-1 levels as well as inhibit 5-LOX.
¨ìMay Improve Diabetes
In animal models, J147 Powder has shown to decrease blood Glucose and HbA1c levels by increasing AMPK.
Although not significant, J147 Powder may also enhance the function of residual beta cells in diabetes.
¨íFights Pain And Neuropathy
J-147 Powder was proven to be efficacious in treating Diabetic Neuropathy in an animal model with type 1 diabetes.
It could help reduce diabetes-induced motor nerve dysfunction, peripheral sensitivity, and pain levels.
¨îMay Improve Anxiety
J147 Powder has the ability to reduce anxiety levels.
J147 Powder was able to reduce anxiety levels during maze tests in animal models with AD. |
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medical use
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Molecular Weight:350.3349896
Melt Point:177-178¡ÆC
Color: White or off white powder |
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pharmaceutical |
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AASraw/Aea.ltd
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| Phone |
+13204026693 |
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| Homepage |
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| E-mail |
King@aea.ltd
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| Address |
FLAT/RM C1 4/F SUMMIT BUILDING 30 MAN YUE STREET HUNG HOM,HONG KONG,CHINA |
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