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Orlistat powder
C29H53NO5
96829-58-2
Orlistat powder is a drug used for the treatment of obesity or overweight patients.It was first developed by Roche and launched in the United States in 1999.It is the only over-the-counter weight loss drug approved by FDA,CFDA and EMA in the world.It works by inhibiting pancreatic and gastric lipases,the enzymes responsible for breaking down dietary fats in the gastrointestinal tract.This causes undigested fat to be excreted in the feces,resulting in fewer calories absorbed from fat.

In the United States,orlistat is approved for the treatment of body mass index (BMI,Body Mass Index,unit kg/§³) reaching or exceeding 30 (the US obesity standard).And,people with a body mass index between 27 and 30 and other health risk factors such as high blood pressure or diabetes.
Benefits:
1.Treatment of Obesity
Orlistat powder is primarily used for the treatment of obesity in conjunction with a healthcare provider-supervised reduced-calorie diet.Its primary function is to prevent the absorption of dietary fats by acting as a lipase inhibitor,thereby reducing caloric intake.AASraw Orlistat powder works by inhibiting gastric and pancreatic lipases,the enzymes responsible for breaking down triglycerides in the intestine.When lipase activity is blocked,triglycerides from the diet are not hydrolyzed into absorbable free fatty acids,and instead are excreted unchanged.

2.Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications,such as diet and exercise,lose about 2–
3 kilograms (4–
7 lb) more than those not taking the drug over the course of a year.Between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass,although not all of this mass was necessarily fat.Between 16.4% and 24.8% achieved at least a 10% decrease in body fat.It is worth noting that after orlistat was stopped,a significant number of subjects regained weight—
up to 35% of the weight they had lost.

3.Reduction of Blood Pressure
In addition to aiding in weight loss,studies have shown that orlistat powder can also lead to a modest reduction in blood pressure.Pooled data from clinical trials suggest that orlistat reduces systolic and diastolic blood pressure by an average of 2.5 and 1.9 mmHg,respectively.The mechanism behind this reduction in blood pressure is thought to be related to the weight loss achieved through orlistat use,as obesity is a known risk factor for hypertension.However,it is important to note that the reduction in blood pressure achieved through orlistat use is relatively small and should not be relied upon as the sole treatment for hypertension.People with hypertension should continue to follow the advice of their healthcare provider and use medication as prescribed.
4. Prevention of Onset of Type 2 Diabetes
Orlistat powder has been shown to have a preventive effect on the onset of type 2 diabetes,besides its weight loss and blood pressure-lowering effects.This is likely due to the fact that obesity is a major risk factor for developing type 2 diabetes,and orlistat can help with weight loss in obese individuals.Studies have shown that orlistat can reduce the incidence of type 2 diabetes in people who are obese around the same amount that lifestyle changes do.The exact mechanism by which orlistat prevents the onset of type 2 diabetes is not well understood,but it is thought to be related to the drug¡¯s ability to reduce caloric intake by inhibiting the absorption of dietary fat,which may lead to improved glucose metabolism and insulin sensitivity.It is important to note that orlistat is not a substitute for a healthy lifestyle,and its use should always be combined with a reduced-calorie diet and exercise for maximum effectiveness.
medical use
Molecular Weight:495.7
Melt Point:50 ¡ÆC
Color: White powder
Industrial field pharmaceutical
AASraw/Aea.ltd
Phone +13204026693
Fax
Homepage -
E-mail King@aea.ltd
Address FLAT/RM C1 4/F SUMMIT BUILDING 30 MAN YUE STREET HUNG HOM,HONG KONG,CHINA
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