| Pirfenidone CAS 53179-13-8 of Pulmonary Fibrosis |
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| Pirfenidone CAS 53179-13-8 of Pulmonary Fibrosis |
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| 53179-13-8 |
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Pirfenidone CAS 53179-13-8 of Pulmonary Fibrosis
Product name:Pirfenidone
CAS Number: 53179-13-8
MW: 185.22
MF : C12H11NO
Sample: Avaiable
Category:Antiinflammatory Agents
Min order: 10grams
Quality standard : Enterprise standard
Place of Origin:China
usage The new anti-fibrotic material, with broad-spectrum anti-lung, liver, kidney, heart, and peritoneal fibrosis
Character:White powder
Applications£ºPharmaceutical raw materials
Application:
Esbriet (pirfenidone) is an anti-inflammatory drug used to treat idiopathic pulmonary fibrosis.Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.
Introduction:
In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
Competitive Advantage:
1 High quality with competitive price:
1) Standard: Enterprise Standard
2) All Purity¡Ã98%
3) We are manufacturer and can provide high quality products with factory price.
2 Fast and safe delivery:
1) Parcel can be sent out in 24 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ¡Ã99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3 We have clients throughout the world:
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
Email:sales09 at ycphar dom com
Skype:sales09_109
Telephone:86-027-50756084
Mobile:86-18872220656
|
 |
Pirfenidone CAS 53179-13-8 of Pulmonary Fibrosis
Product name:Pirfenidone
CAS Number: 53179-13-8
MW: 185.22
MF : C12H11NO
Sample: Avaiable
Category:Antiinflammatory Agents
Min order: 10grams
Quality standard : Enterprise standard
Place of Origin:China
usage The new anti-fibrotic material, with broad-spectrum anti-lung, liver, kidney, heart, and peritoneal fibrosis
Character:White powder
Applications£ºPharmaceutical raw materials
Application:
Esbriet (pirfenidone) is an anti-inflammatory drug used to treat idiopathic pulmonary fibrosis.Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.
Introduction:
In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
Competitive Advantage:
1 High quality with competitive price:
1) Standard: Enterprise Standard
2) All Purity¡Ã98%
3) We are manufacturer and can provide high quality products with factory price.
2 Fast and safe delivery:
1) Parcel can be sent out in 24 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ¡Ã99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3 We have clients throughout the world:
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
Email:sales09 at ycphar dom com
Skype:sales09_109
Telephone:86-027-50756084
Mobile:86-18872220656
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