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pharmaceutical
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Lincomycin Hcl
Synonyms: Lincomycin Hydrochloride
CAS: 859-18-7
EINECS 212-726-7
Assay: 82.5~95.5%
Standard: EP7.0/BP/USP
Packing: 20Bou/cardboard drum
MF: C18H35ClN2O6S
MW: 443
Character: White crystalline powder. MP 156-158¡ÆC, PH3.5~5.5, Optical rotation +135~+150¡Æ. Solubility: H2O: 50 mg/mL, clear, colorless.
Usage: An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
Lincomycin (hereinafter referred to as LCM) biosynthesis, in addition to produce LCM, but under certain conditions, also produced the LCM B, C, D, K, S and other analogues, thus refining process more difficult and costly.
LD50 acute toxicity test showed that mice injected 1000mg/kg, rat oral greater than 4000mg/kg, toxicity is low.
Indications: Effect as erythromycin, do not have to do skin test, the product of Gram-positive bacteria and gram-negative bacteria is stronger for osteomyelitis, sepsis, respiratory and soft tissue infections. This product is very strong penetration of bone, is the medicine of choice for osteomyelitis.
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